Resolution of Conformational Activation in the Kinetic Mechanism of Plasminogen Activation by Streptokinase
نویسندگان
چکیده
منابع مشابه
Mechanism of activation of human plasminogen by streptokinase. Presence of active center in streptokinase-plasminogen complex.
The role of proactivators for the streptokinase activation of human plasminogen was studied. It was found that plasmin, as well as plasminogen, can form activator complex with streptokinase. The relative importance of these two proactivators for the streptokinase activation of human plasminogen is discussed. The use of the active center-specific reagent, p-nitrophenylp-guanidinobenzoate (NPGB) ...
متن کاملThe activation of human plasminogen by streptokinase.
Human plasma contains a proteolytic enzyme precursor termed plasminogen (I) or profibrinolysin (2), which, upon activation by physical agents or specific bacterial kinases, is converted to plasmin (1) or fibrinolysin (2). Streptokinase (henceforth referred to as SK), an extracellular hemolytic streptococcal product, has been a commonly used activator for human plasminogen. Two mechanisms have b...
متن کاملPlasminogen Activation With Streptokinase
Background. Platelet activation occurs in vivo during pharmacologic thrombolysis and may contribute to recurrent thrombosis. Plasmin does not directly activate platelets except at high concentrations; thus, the mechanisms for platelet activation during thrombolysis remain undefined. Increases in thrombin activity also occur in patients treated with fibrinolytic agents and may contribute to acti...
متن کاملstudy of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
Mechanism of Activation of Human Plasminogen by the Activator Complex, Streptokinase
The object of this investigation was to distinguish between two potential mechanisms of activation of human plasminogen (HPg) to plasmin (HPm) by catalytic levels of the activator complex, streptokinase.plasmin (SK* .HPm). One mechanism, which is widely supported, postulates an enzymatic role for SK*. HPm in the conversion of molar excesses of plasminogen to plasmin. A more recently described k...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m405264200